What is the patho physiology of abdominal aortic aneurysm?

March 11 21:21 2019 Print This Article

There are some noticeable changes seen in the tunic media and intima. The lipid cells are accumulated in the foam cells. There are free cholesterol crystals in the extracellular fluid. The calcification, thrombosis and ulceration along with the rupture of layers are seen. An inflammatory infiltrate in the adventitia is seen.

The tunica media breaks by the process of proteolysis. It is considered to be the basic mechanism of triple A development. The individuals with this defect show an increased expression and activity of metallo proteinases. It removes the elastin from media and making the wall of aorta more susceptible to the blood pressure. The vasa vasorum is reduced in the abdominal aorta. The tunica media depends mostly on the process of diffusion for nutrition which makes its susceptible to the injury.

The hemodynamic affects the triple A and has an affinity for the infra renal aorta. The infra renal aorta differs from the thoracic aorta in the histo pathological and mechanical features. As we move to the bifurcation the diameter decreases and the abdominal aorta wall has less amount of elastin. The abdominal aortic wall has higher mechanical tension than the thoracic aortic wall. The elasticity and the distensibility decreases as the age increases.

The individuals with the higher hypertension have higher intra luminal pressure which may lead to the increase of pathological process.

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