What is the history of Acute myeloblastic leukemia type 5?

March 07 23:21 2019 Print This Article

In the first published description of a case of leukemia in the medical literature dates back to the year 1827. The French physician described Alfred armand Louis marie valpeau described the 63 year old florist who developed an illness which showed fever, weakness, urinary stones along with the enlargement of spleen and liver. He noted that the blood of the patient has gruel like consistency. The appearance of the blood was due to the white corpuscles.

In the year 1845 there were many patients which died due to the enlarged spleen and changes in the color and consistencies of blood. It was reported by the Edinburg pathologist known as J H Bennett. He used the term leuco cythemia to describe the pathological condition.

The term leukemia was coined by the German pathologist Rudolf Virchow in the year 1856. He was a pioneer in the field of light microscopy and he describes the excess of white blood cells seen in the patients with clinical syndrome described by the Velpeau and Bennett. The cause of excess of white blood cells was not known by the Virchow and he used the descriptive term leukemia to refer to the condition. The development of the new technology leads to the further advancement in the understanding of acute myeloid leukemia.

In the year 1877 Paul developed a technique with the help of blood staining films which help to know about the normal and abnormal white blood cells. There was an author W. Ebstein who described the acute leukemia.

In the year 1889 it was differentiated into rapidly progressive and fatal form. The myeloid was coined by the Neumann in the year 1869. He came to conclusion that the white blood cells came from the bone marrow not in the spleen. A Mosler described the technique to examine the bone marrow so that leukemia can be diagnosed. It was done in the year 1879. The malignant cell in the AML was known as the myeloblast in the year 1900. It was characterized by Nageli who divided the leukemia into myeloid and lymphocytic.

In the year 2008 this became the first cancer to be properly sequenced. The leukemic cell DNA was extracted from the unaffected skin. The leukemic cell contains acquired mutations in many genes which is not associated with the disease.

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