What is the classification of Acute myeloblastic leukemia type 4?

March 07 22:36 2019 Print This Article

There are many classifications which are linked to this disorder. It includes the world health organization classification, French American British classification and un common phenotypes of acute myeloid leukemia. In the world health organization classification the acute myeloid leukemia is more useful clinically and produces a good prognosis than the other classifications. The WHO contains many sub categories of interest to the hemato pathologist and oncologist. It is mainly done by the categorization into different sub types. They have divided AML as AML with the genetic abnormalities and AML with the multi lineage dysplasia, AML and MDS therapy related and not categorized AML. The AML with the genetic abnormalities includes the trans locations between different chromosomes. It includes the chromosome 8 and 21.

There are inversions seen in the different chromosomes 16. There are trans locations between chromosome 15 and 17. The patients with this disorder have a high rate of remission and have a better prognosis. The multi lineage dysplasia, AML and MDS with the myelo proliferatve disease can be transformed into the AML. It occurs in the elderly patient and has a worst prognosis. In the case of AML and MDS therapy the patients had prior chemo therapy or radiation and develop AML or MDS. They have a worst prognosis and have specific chromosomal abnormalities. In the non categorized types one includes all the left AML types.

The acute leukemia’s of ambiguous lineage which is also known as the mixed phenotype or bi phenotypic acute leukemia. It occurs when the leukemic cells cannot be classified as myeloid or lymphoid cells. Both types of cells are present. The French American British classification divided AML into 8 different sub types. They range from M0 to M7. They are divided on the basis of cells from which the leukemia develops and its degree of maturity. It is done with the help of examining the cells by the use of light microscope and cyto genetics. This system is widely used but the WHO system is more successful. The examination of cells helps us to know about the chromosomal abnormalities. The different sub types have different prognosis and their response to the therapy.

The M1 is also known as the acute myeloblastic leukemia without maturation. The M0 is also known as the minimal differentiated acute myeloblastic leukemia. The M2 is also known as the acute myeloblastic leukemia with granulocytic maturation. The M3 is also known as the acute pro myelocytic leukemia. The M4 is also known as the acute myelo monocytic leukemia. The M4eo is also known as the myelo monocytic leukemia along with the bone marrow eosinophilia. The M5 is also known as the acute monoblastic leukemia or acute monocytic leukemia. The M6 is also known as the acute erythroid leukemia which includes the erythro leukemia or very rare pure erythroid leukemia. The M7 is also known as the acute myelo mega karyoblastic leukemia. The M8 is also known as the acute basophilic leukemia.

In the un common phenotypes there are rare types of AML which are not included under the other classification systems. However, most of them are included under the WHO system except acute myeloid dendritic cells. It includes the acute basophilic leukemia and acute eosinophilic leukemia. The mast cell leukemia and myeloid sarcoma are also included under it. The acute myeloid dendritic cell leukemia and acute panmyelosis are also included under it.

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