What Is A Chronic Infantile Neurologic Cutaneous And Articular Syndrome Or Disease?

March 22 22:24 2019 Print This Article

It is defined as a disorder in which there is a fever which occurs at periods. It is rare and genetic in nature. It is also known as the neo natal onset multi system inflammatory disease. It leads to inflammation which cannot be controlled and involve many parts of the body. It occurs in the new born time and may lead to rashes, arthritis, as well as brain and nerve function. It is in link with the cryopyrin. It occurs due to the mutations seen in the CIAS 1 gene and it regulates the inflammation. There are mutations in the gene which lead to familial cold urticaria as well as other syndrome. The disease can be treated with the help of anakinra.

What are the signs and symptoms of chronic infantile neurologic cutaneous and articular syndrome or disease?

It includes the new born time and may lead to rashes, arthritis, as well as brain and nerve function. It is in link with the cryopyrin. The symptom varies from one patient to other. Arthritis is seen in most of the patients. It leads to problem in the joints. A few of them have a pain in the joint. The children have a short height. One can also see hives which are not itchy. Rash is the earliest symptom. Most of the patients have a have problem in the nerve and suffer from headache, vomiting as well as seizures. It can also occur from the inflammation seen in the brain. The inflammation may be also seen in the eyes and can lead to loss of vision. One also has hearing problems and anemia is also seen. Fever is also episodic.

What are the causes of chronic infantile neurologic cutaneous and articular syndrome or disease?

It includes due to the mutations seen in the CIAS 1 gene and it regulates the inflammation. There are mutations in the gene which lead to familial cold urticaria as well as other syndrome. Most of the patients do not have the same gene and there is a disorder which is not inherited but it is genetic. In children it is also seen. It controls the immune system so the effected gene also leads to inflammation which cannot be controlled.

How chronic infantile neurologic cutaneous and articular syndrome or disease can be diagnosed?

It includes the use of visual examination and a personal history. One must keep a check on the signs as well as symptoms. No specific tests can be known and there is a blood test which can be done so that one can rule out the process of inflammation. The gene which causes this effect may change later in the life.

How chronic infantile neurologic cutaneous and articular syndrome or disease can be treated?

It can be treated with the help of anakinra. There is no other specific treatment for it. One must control the inflammation as soon as possible. One must go for steroids but they have a long list of side effects. One can also use methotrexate or colchicines. They have been successful and this is a supportive treatment and it mainly controls the symptoms.

How chronic infantile neurologic cutaneous and articular syndrome or disease can be prevented?

It includes the avoidance of any irritating factor. The patients with this disorder have risk of other problems. The nerves are also troubling and one must understand the disease properly.

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