What Is A Buruli Ulcer Disease?

March 22 21:55 2019 Print This Article

It is defined as a disorder in which there is an infection which is caused by the M Ulcerans. It is also known as the searles ulcer. In the early stage there is a formation of the nodule which is non painful. It is non pyogenic as well as lead to the lesions which are necrosed. They are present in the bone and work as the disease progresses. There are few species of mycobacteria which releases the toxins and it gives rise to immune suppressant as well as necrotizing agent and starts the apoptosis process in human tissue. It was described in the year 1948 in the south east Australia by Bairns dale district personnel J A Grant. The name of disease is derived from the country Uganda in which the disease was quite prevalent. It occurred in the 1960s. The disease is transmitted in the water not from a person to other.

What are the signs and symptoms of Buruli ulcer disease?

It includes the nodule which is non painful. It is non pyogenic as well as lead to the lesions which are necrosed. They are present in the bone and work as the disease progresses. There are few species of mycobacteria which releases the toxins. In few cases there can be a pimple in the skin. The infection occurs in the limbs also. It occurs on the exposed areas and does not include the hands or feet. In case of children all areas are involved and it includes the abdomen as well as face. If the infection is severe it can lead to the swelling of limb which is not concrete. It does not resemble the papule or pimple. In this case fever can occur along with a pain. The physical trauma can occur along with the infection. It could be a scratch or trauma.

What are the causes of Buruli ulcer disease?

It includes the infection in case of sub cutaneous fat. In this there is a formation of the dead fat which has many mycobacteria. They form the spherules. One can also see the ulcers of skin in the later stage. There are few species of mycobacteria which releases the toxins and it gives rise to immune suppressant as well as necrotizing agent and starts the apoptosis process in human tissue. The disease progress slowly and the healing occurs as soon as possible. It can also lead to ulcers, granulation as well as scarring. The nodules develop and can lead to secondary infections. It may include the bone. It can also lead to death. It can also lead to morbidity as well as deformity. The mediated immune response known as TH 1 is protected against the M ulcerans but the TH 2 is not.

How Buruli ulcer disease can be diagnosed?

It includes the use of visual examination as well as history taking. One can also go for the PCR test. It is not specific for the bacteria. One can also go for the Z Neelsen staining. It is 60 percent sensitive and the culture is less sensitive.

How Buruli ulcer disease can be treated?

It can be treated with the help of a surgery which includes the surgical excision. It is only a minor surgery. In early stages if it is done the results are good. If the disease is prolonged than the skin grafting can be done. In the developing countries there is not a good result of the surgery.

The role of antibiotics is very limited and the treatment mainly relies on the usage of rifampicin as well as streptomycin. It is taken for 8 weeks so that one can avoid the surgery. In Australia one can take a combination of rifampicin as well as clarithromycin. One must not use rifampicin alone otherwise it can become resistant.

One can use few experiment medicines such as the combination of rifampicin as well as sitafloxacin. The most potent antibiotic is rifalazil. One can also use a combination of epiroprim as well as dapsone. One can also use French clay along with a diaryl quinolone. One can also use a local heat around 4o degree Celsius which leads to full healing. There is no need of surgery.

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