Bullous Pemphigoid – Causes, Symptoms & Treatment

March 19 21:50 2019 Print This Article

Bullous pemphigoid is a chronic, autoimmune, subepidermal, blistering blistering disease that can occur at any age but usually occurs in people over fifty years of age. Bullous is the medical term for a large blister. It ranges from mildly itchy welts to severe blisters and infection, and may affect a small area of the body or be widespread. The blisters are large and can occur anywhere on the skin but are more common on the skin fold areas such as the groin and armpits. Bullous pemphigoid can also involve the mouth. This disease is not a fatal disease and is usually cured easily. Lesions are concentrated on the inner arms and inner thighs and may appear on an erythematous or a non-erythematous base. One-third of patients have oral lesions. Bullous pemphigoid can be chronic, mild and not affect the general health or it can be severe and compromise the health of the sufferer. The diagnosis can be confirmed by a skin biopsy showing the abnormal antibodies deposited in the skin layer. Treatment is with topical cortisone creams, but especially severe cases may sometimes require high doses of cortisone-like drugs (steroids) or immune suppression drugs, such as azathoprine (Imuran).

Bullous pemphigoid is a rare, chronic condition in which fluid-filled blisters (bullae) erupt on the surface of your skin, usually on your arms and legs. The cause of bullous pemphigoid is unknown, but it may be related to a disorder of the immune system. Bullous pemphigoid tends to occur mainly in older people. It is a less serious disease than pemphigus, is rarely fatal, and does not result in widespread peeling of skin. It can involve a large portion of the skin, however, and can be very uncomfortable. In bullous pemphigoid, the immune system forms antibodies directed against the skin, resulting in large, tense, very itchy blisters surrounded by areas of red, inflamed skin. Blisters in the mouth are uncommon and are not severe. The areas of skin that are not blistered appear normal. Although this type of medical condition does not arise too often, it is important to relay some general information regarding this illness so that individuals afflicted with a disorder of this type may have something as a reference.

Causes of Bullous Pemphigoid

Bullous pemphigoid is an autoimmune disease, which means something causes the immune system to attack healthy tissues in the body, in this case the skin. This means your immune system, for some unknown reason, begins to think that parts of your skin are  foreign invaders. A number of drugs such as penicillin and furosemide can bring about the appearance of the blisters. The burns of radiation and the sun can bring about the appearance of the blisters also. People who suffer from other immune disorder such as diabetes can suffer sometimes from Bullous Pemphigoid also.

Find common causes and risk factors of Bullous Pemphigoid

  • Some viruses, infection, prolonged sitting in sunlight, or other factors can also lead to the condition of bullous pemphigoid.
  • The side-effects due to some medicines – like furosemide, sulphasalazine, penicillins, and captopril may lead to formation of bullous pemphigoid.
  • It is not contagious disease i.e. cannot be transmitted from one person to other.
  • Pernicious anaemia, rheumatoid arthritis, and vitiligo are also one of the main causes of bullous pemphigoid.

Signs and Symptoms of Bullous Pemphigoid

Sign and symptoms may include the following:

  • Mouth sores.
  • Itching.
  • Rashes.
  • Bleeding gums.
  • Gum or mouth sores.

Treatment for Bullous Pemphigoid

Treatment of bullous pemphigoid can resolve with topical cortisone creams, but sometimes requires high doses of cortisone (“steroids”) taken internally. Severe bullous pemphigoid can also require immune suppression drugs, such as azathoprine (Imuran).

Treatment may include:

  • The topical cortisone creams can resolve bullous pemphigoid, but sometimes requires high doses of cortisone taken internally.
  • Topical Steroids are very effective, usually clobetasol propionate for the fast recovery.
  • The skin infection can be controlled by using drugs, like Dapsone, Prednisone and Imuran.
  • Nicotinamide may also be used in the chronic condition.
  Article "tagged" as: