What is an Acitretine Antenatal Infection?

April 21 22:46 2019 Print This Article

It is defined as a condition in which there occur a second generation retinoid known as the acitretin. Its mode of administration is oral. It is used in the treatment of psoriasis. It is a byproduct of etretinate. It was used before the acitretin was introduced. It was discontinued as it had a narrow therauptic range and has a long half life. However, the acitretin had a half life of 2 days. The acitretin can be reverse metabolized into the etretinate which has a long half life. The women must avoid becoming pregnant for 2 years when they discontinue acitretin.

The etretinate is not recommended for the women who have the ability to bear the child and risk of becoming pregnant. The least toxic treatment for psoriasis is acitretin. It is quite successful in the treatment of severe cases of psoriasis. It has the ability to bind with the nuclear receptors which regulate the transcription of gene. They induce the differentiation of keratinocyte and decreases the epidermal hyperplasia. The acitretin is absorbed readily and is distributed widely after it’s absorbed orally. The therauptic effect occurs after 2 to 4 weeks. If the patient receives the medicine he is advised against giving blood indefinitely as there is a risk of birth defects.

What are the signs and symptoms of Acitretine antenatal infection?

It includes the heart, ear and cranio facial malformations.

What is the treatment of Acitretine antenatal infection?

There is no specific treatment for this disorder.

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